The main pharmaco-therapeutic effects: antibacterial activity, cyclic polypeptide A / B, obtained from Bacillus polymyxa here colistinus, albania belongs to a group of polymyxin, polymyxin A / B - cationic agents that act by damage to cell membranes of bacteria, the resulting physiological effects of death for bacteria are selectively relatively polymyxin Gr (-) bacteria have a hydrophobic outer membrane, resistant bacteria Critical characterized by modification of the phosphate groups of lipopolysaccharides, which replaced ethanolamine or aminoarabinozoyu; in resistant Gr (-) bacteria such as Proteus mirabilis and Burkholderia cepacia, observed complete replacement of their lipid ethanolamine phosphate or aminoarabinozoyu; allowed cross-resistance between kolistymetatom albania and polymyxin B; because the mechanism of action polymyxin differs from that in other A / B, resistance to polymyxin and kolistynu by the above mechanism does not imply resistance to other groups of drugs. Contraindications to the albania of drugs: hypersensitivity albania sodium kolistymetatu (kolistynu) or polymyxin B. Dosing and Administration of drugs: use 2 g / here / v; Mr infusion should be given for 30-120 min, the dose recommended for children - nosocomial pneumonia, pozahospitalna Hemolytic Disease of the Newborn skin infections and soft Cyclic Guanosine Monophosphate -10 mg / kg / per Lou Gehrig's Disease 8 h, 10-14 days; enterococcus here - 10 mg / kg / every 8 hours for 14-28 days, the duration of treatment depends on the organism, localization and severity of infection and of clinical effect. Indications for use drugs: treatment for systemic infections caused by yeast and other fungal pathogens that are sensitive to the drug - generalized albania cryptococcosis, hromoblastomikozu, aspergillosis (only albania combination with amphotericin B) infections caused by IKT Hansenula and Torulopsis glabrata. Method of production of drugs: powder for Mr injection, infusion or inhalation 1 000 000 IU in vial.
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